Prog Neuropsychopharmacol Biol Psychiatry. Genetics of borderline personality disorder: systematic review and proposal of an integrative model. Second, the types of environments that can put children at risk of developing BPD also run in families. Genetics, environmental factors, and brain abnormalities are thought to play a role. According to the National Institute of Mental Health, borderline personality disorder (BPD) is more common than schizophrenia or bipolar disorder and is … Borderline personality disorder is a complex condition that emerges from a complicated web of causation. 11. A study on twins and BPD published in the Journal of Personality Disorders suggests the disorder has a substantial genetic component. Serotonin genes and gene-gene interactions in borderline personality disorder in a matched case-control study. An exploration of whether borderline personality disorder stems from genetic factors or others leads us to the treatment solutions that are available. According to several studies, the onset of the Borderline Personality Disorder (BPD) depends on the combination between genetic and environmental factors (GxE), in particular between biological vulnerabilities and the exposure to traumatic experiences during childhood. Clinicians have been reluctant to reveal the diagnosis to patients because of the stigma attached to it. BPD may be a genetic condition. 2 BPD is associated with high rates of suicide — nearly all BPD patients have experienced suicidal ideation and almost 10% commit suicide by adulthood. Neurosci Biobehav Rev. Borderline personality disorder (BPD) is often co-morbid with major depression and may complicate its treatment. The topic of ‘genetics’ is a lazy fool’s game, and anybody eager to attribute Borderline Personality Disorder to genetics is a lazy fool. The study of Borderline personality disorder (BPD) is prevalent, affecting as many as 1% to 2% of the general population, 1 and this incidence rises as high as 15% to 20% in psychiatric settings. … 12. 3 Although psychosocial causes of BPD have been explored in many … 2009;33:128-133. At the same time, the book offers a serious scientist's comprehensive review of neuroscientic, genetic and historical studies of borderline personality disorder (BPD). 2014;40:6-19. First, some part of BPD is due to genetics; if these are your biological kids and they have inherited a certain combination of genes from you, they may be more at risk to develop BPD. Causes of Borderline Personality Disorder For many years, it was commonly believed that the main cause of borderline disorder was poor or uninformed parenting. But individuals with BPD suffer terribly and a significant proportion die by suicide and engage in nonsuicidal self-injury. Borderline Personality Disorder (BPD) is thought to arise from both environmental and genetic factors. Ni X, Chan D, Chan K, et al. Amad A, Ramos N, Thomas P, et al. Many researchers even questioned its existence. BPD have been explored in many studies, relatively little data exist regarding biological causes. From twin studies, the concordance rate for having BPD for monozygotic twins has been found to be 35-69% [] while the concordance rate for dizygotic twins is only 7% [].This indicates that there is a genetic contribution to the development of BPD. You see, by attributing it to genetics, the professional community spares themselves from truly having to explain it in practical, relevant terms that demonstrate genuine understanding and insight. Experts do not know what causes BPD.

Until recently, borderline personality disorder (BPD) has been the stepchild of psychiatric disorders. The neurological and genetic factors of BPD have not yet been fully explored, perhaps be-cause it is difficult to find BPD subjects to participate or be-cause the technologies used are relatively young.