The identification of the second locus, the fat mass- and obesity-associated gene (FTO), has been more robustly observed by others. 266–274, 2010. The fat mass and obesity-associated gene (FTO) is a well-replicated gene locus of obesity ().It was originally identified as a gene locus of type-2 diabetes, and only later it was discovered that it increases risk of this disease through its primary effect on adiposity ().However, the mechanisms through which FTO may increase adiposity are still not clear. Farooqi S, O’Rahilly S. Genetics of obesity in humans. The genetics of obesity: FTO leads the way. The genetics of obesity is complex and multifactorial and, like other complex genetic disorders, no single gene makes more than a small contribution to individual risk. Web. In 2007, an association of single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) gene region with body mass index (BMI) and risk of obesity was identified in multiple populations, making FTO the first locus unequivocally associated with adiposity. “FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.” The New England journal of medicine 373.10 (2015): 895–907.

2. At the time, FTO was a gene of unknown function and it was not known whether these SNPs exerted their effect on adiposity by affecting FTO or neighboring genes. Genetic and environmental factors in relative body weight and human adiposity.

2010; 26 (6):266–274. Trends in Genetics. Association analysis of the FTO gene with obesity in children of Caucasian and … Obesity Associated Genetic Variation in FTOIs Associated with Diminished Satiety. [ PMID 20421936 ] Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.

In 2007, an association of single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) gene region with body mass index (BMI) and risk of obesity was identified in multiple populations, making FTO the first locus unequivocally associated with adiposity.
“The Genetics of Obesity: FTO Leads the Way.” Trends in Genetics 26.6 (2010): 266–274. (2010). At the time, FTO was a gene of unknown function and it was not known whether these SNPs exerted their effect on adiposity … The genetics of obesity: FTO leads the way. 1997; 27:325-51.

Metabolic Disease Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK. Fawcett KA 1, Barroso I. The genetics of obesity: FTO leads the way Katherine A. Fawcett 1 and Inês Barroso 1, 2 1 and Inês Barroso 1, 2 PMC. The genetics of obesity: FTO leads the way. Thus, although the influence of FTO on obesity is modest, FTO remains the most replicated and consistently reported obesity-risk gene (Fawcett and Barroso, 2010). Trends Genet. The genetics of obesity: FTO leads the way. Endocr Rev.

The role of FTO gene polymorphism in the pathogenesis of obesity.
The prevalence of obesity, which is a heritable trait that arises from the interactions of multiple genes and lifestyle factors, continues to increase worldwide, causing serious health problems and imposing a substantial economic burden on societies. 2006; 27:710-18.

Behav Genet. 3. Fawcett, K. et al. These studies suggested that FTO plays a role in controlling feeding behavior and energy expenditure… At the time, FTO was a gene of unknown function and it was not known whether these SNPs exerted their effect on adiposity … In 2007, an association of single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) gene region with body mass index (BMI) and risk of obesity was identified in multiple populations, making FTO the first locus unequivocally associated with adiposity. Maes HH, Neale MC, Eaves LJ. Dina C, Meyre D, Gallina S, et al. Trends Genet. Variation in FTO contributes to childhood obesity and severe adult obesity. Faith MS, Rha SS, Neale MC, Allison DB. 266–274, 2010.