Although most Robertsonian translocation carriers are healthy and have a normal lifespan, they are at increased risk of spontaneous abortions and risk of producing unbalanced gametes and, therefore unbalanced offspring. Robertsonian translocation: 46, XX, +21, rob (21;21) (q10;q10). They have played an important role in the evolution of both plants and animals as demonstrated by organisms within a species (or in closely related species) that have different chromosome numbers but the same … Introduction.

Here we reported a previously undescribed Robertsonian translocation. We know that chromosomes seem to break and rejoin quite often, and it is only sometimes that this leads to problems. Abstract.

Robertsonian translocations occur in approximately one in every 1000 newborns.

Comprehensive chromosome screening was performed in 107 embryos from 11 couples carrying Robertsonian translocations. those involving two different acrocentric chromosomes—either two different D group chromosomes (chromosomes 13, 14 and 15), two … Among them, embryos from 2 families had been transferred before the diagnosis of translocation, which resulted in successful pregnancies; embryos from the remaining families were transferred after the identification of translocations.

Despite this no generalizations should be based on such findings. although about 1 person in 500 has a translocation, we still do not really understand why they happen. Why do translocations happen? Robertsonian translocations (centric fusion of two acrocentric chromosomes) occur with a prevalence of ∼1 in 1000 in the general population (Gardner and Sutherland, 1996).By far the most common are the nonhomologous forms, i.e. A Robertsonian Translocation This occurs when two whole chromosomes become “stuck together”. Robertsonian translocations refer to the recombination of whole chromosome arms. The odds of two consecutive cases of Down's syndrome due to Robertsonian translocation being missed by chance on NIPT are small.

Of the Robertsonian der (14;21) translocations of known parental origin, 54% were de novo, 41% maternal and 5% paternal and 15.8% of mothers of those of maternal origin had recurrences.

In in vitro fertilization, it is difficult, if not impossible, with current methods to determine whether an embryo carries a chromosomal translocation. Such translocations take place most often between acrocentric or telocentric chromosomes.